The Los Angeles Chargers (5-3) take on the San Francisco 49ers (4-4) in Week 10 on the road in a prime-time matchup. Kickoff at Levis Stadium in Santa Clara is 8:20 p.m. ET (NBC). Below, we analyze Tipico Sportsbook‘s lines around the Chargers vs. 49ers odds, and make our expert NFL picks and predictions.
The Chargers are coming off a 20-17 last-second win over the Atlanta Falcons and have won 4 of their last 5 games.
The 49ers are coming off their bye week. Two weeks ago, they fell behind 14-7 to the Los Angeles Rams, but came back to win 31-14 behind RB Christian McCaffrey, who rushed for a TD, had a TD reception and even threw a TD pass. That win snapped a 2-game losing streak.
FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+
Chargers at 49ers odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:38 a.m. ET.
- Moneyline (ML): Chargers +255 (bet $100 to win $255) | 49ers -310 (bet $310 to win $100)
- Against the spread (ATS): Chargers +7.5 (-113) | 49ers -7.5 (-107)
- Over/Under (O/U): 45 (O: -110 | U: -110)
Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!
Chargers at 49ers key injuries
Chargers
- WR Keenan Allen (hamstring) out
- K Dustin Hopkins (hamstring) out
- G Brenden James (shoulder) questionable
- LB Chris Rumph (knee) doubtful
- T Trey Pipkin (knee) questionable
- WR Mike Williams (ankle) out
49ers
- DL Arik Armstead (foot, ankle) out
- DL Samson Ebukam (quad, Achilles) doubtful
Play our free daily Pick’em Challenge and win! Play now!
Chargers at 49ers picks and predictions
Prediction
49ers 27, Chargers 17
Moneyline
Both teams have been up and down this season and the Chargers have been decimated by injuries. They won’t have their 2 top receivers against a talented defense, and the 49ers appear to be having fun with McCaffrey in the backfield.
The Chargers have found a way to win 4 of their last 5 games, but being shorthanded, I don’t see them upsetting the Niners.
The Niners should win but you shouldn’t worry about wagering the moneyline with the price. PASS.
Against the spread
Both teams’ ATS records match their won-loss records.
The Chargers have covered the spread in 1 game they lost and are 1-0 ATS in the 1 game in which they were the underdog.
The 49ers have covered the spread in all 4 of their wins and all 4 wins have been by at least 12 points.
BET 49ERS -7.5 (-107).
Over/Under
Two of the Chargers’ last 3 games have not reached 45 total points.
Three of the 49ers’ last 4 games have had at least 45 points.
But with the Chargers missing so many passing targets, they won’t be able to do enough themselves.
BET UNDER 45 (-110).
Want action on this NFL game or any other matchups? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!
If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.
Follow Jess Root on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.
Access more NFL coverage:
BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire
[lawrence-newsletter]
[lawrence-auto-related count=3 category=1367]