Buffalo Bills betting odds line spread pick predictions best bets – Page 7

Buffalo Bills at Tennessee Titans odds, picks and predictions: Player prop bets

Analyzing the Buffalo Bills at Tennessee Titans Week 6 matchup and offering up expert picks and predictions on the top player prop bets.

On Monday Night Football, the Buffalo Bills (4-1) visit the Tennessee Titans (3-2). The game is set to kick off at 8:15 p.m. ET and will be held at Nissan Stadium. Below, we look at the Bills vs. Titans prop bet odds and lines, and make our best NFL picks, predictions and bets.

The Bills are coming in this game having beat the Kansas City Chiefs by 18 last week.

They’ve won their last four games by a combined 115 points, shutting out the Texans and Dolphins. This team has just taken their game to a new level behind MVP-favorite Josh Allen.

As for the Titans, they’ll be returning Julio Jones and A.J. Brown. Along with Derrick Henry, who is on pace to break the single-season rushing record, Tennessee has an elite offense as well.

This should be a thrilling game. That said, let’s dive into the player props you should consider taking.

Bills at Titans prop bet picks and predictions

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 7:30 a.m. ET.

Bills QB Josh Allen OVER 292.5 passing yards (-114)

Allen has been on fire over the last few weeks. Having been able to take off the gas against Houston with the Bills annihilating the Texans, Allen has surpassed 293 yards in two of his last three games.

He had 315 yards on 15 completions in a rain-heavy game against the Chiefs. With the Titans ranking 21st in opponents’ passing yards per game, Allen should be able to expose a weak Tennessee pass defense.

Given his strong recent play and a poor Tennessee defense, I’d play the Over for the MVP hopeful.

Titans RB Derrick Henry OVER 13.5 receiving yards (-114)

Derrick Henry was left out of the passing game last week, not seeing a single target.

So far this season, that has been a rarity. Henry has surpassed 13 yards in all four of the team’s other games this season. He’s 4-for-5 on this prop this season.

With the clear strength of this team being his ability to run, that is the focal point for defenses. Buffalo has given up more than 20 receiving yards to running backs in its last four games.

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Bills WR Emmanuel Sanders Anytime TD scorer (+155)

Allen has been electric, and Emmanuel Sanders has become a key end zone threat for him. Sanders has had four touchdowns in the Bills’ last three games.

With Allen surging, Sanders, an offseason addition for Buffalo, has continued as a top weapon. He has seen at least five targets in all five of Buffalo’s games this season.

This should be a high-scoring game with Buffalo having put up at least 35 in four straight games. Expect Allen to score often, and with Sanders becoming a red-zone favorite, he should get a couple of chances to score.

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Buffalo Bills at Tennessee Titans odds, picks and prediction

Analyzing Monday’s Buffalo Bills at Tennessee Titans odds and lines, with expert NFL picks, predictions and best bets.

The Buffalo Bills (4-1) travel to meet the Tennessee Titans (3-2) at Nissan Stadium for Monday Night Football in Week 6. Kickoff is scheduled for 8:15 p.m. ET and the game is televised on ESPN. Below, we look at the Bills vs. Titans odds and lines, and make our best NFL picks, predictions and bets.

The Bills picked up their fourth consecutive win and cover in Kansas City Sunday night in Week 5. The Buffalo offense has been on fire, too, going for 35 or more points in four straight outings.

The Titans registered a 37-19 win on the road against the Jacksonville Jaguars in Week 5, bouncing back from a stunning overtime loss against the New York Jets in the previous week. The Under has cashed in each of Tennessee’s previous two games at home.

Bills at Titans odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 7:25 a.m. ET.

Money line: Bills -260 (bet $260 to win $100) | Titans +205 (bet $100 to win $205)
Against the spread (ATS): Bills -5.5 (-117) | Titans +5.5 (-103)
Over/Under (O/U): 53.5 (O: -105 | U: -115)

Bills at Titans key injuries

Bills

No notables injuries to report

Titans

RB Jeremy McNichols (ankle) questionable
WR Chester Rogers (groin) questionable

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Bills at Titans odds, lines, predictions and picks

Prediction

Bills 30, Titans 27

Money line

The Bills (-260) are playing a second consecutive marquee, nationally televised game against a top AFC opponent for the second straight week. Buffalo proved in Kansas City that it is here to stay, but can they bring it for a second straight outing?

AVOID, as risking more than two-and-a-half times your potential return on a road team against a top-tier team is not a good betting strategy.

Against the spread

The TITANS +5.5 (-103) have a couple of depth players who will be sidelined, but the most important thing is that WRs A.J. Brown and Julio Jones are back and healthy. Tennessee has the horses on offense to hang right with Buffalo, especially on its home field in front of a raucous crowd.

Over/Under

The OVER 53.5 (-115) is the play in this Monday nighter. Buffalo’s offense has been on fire lately, and Tennessee is healthy and ready to roll. That extra day between last week’s layup at Jacksonville, and this matchup will really serve them well. Look for plenty of points.

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Underdog corner: 3 best NFL picks and predictions for Week 6

Assessing the NFL betting odds and lines for Week 6, with three predictions and picks for the best ATS underdog bets to make.

NFL pointspread favorites enjoyed their first winning week of the season in Week 5, but were unfazed here in Underdog Corner, hitting on two of our three selections to notch our fourth winning week of the season.

With the Cincinnati Bengals and Buffalo Bills cashing, it ups our 2021 record to a nice and profitable 11-4 (.733).

Let’s see if we can keep the train rolling with our NFL underdog ATS picks and predictions of Week 6.

Also see: All Week 6 odds and lines

NFL underdog predictions: Week 6

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 6:41 p.m. ET.

Jacksonville Jaguars +3.5 (-117) vs. Miami Dolphins

The NFL is serving up another London dud as the winless Jaguars take on the 1-4 Dolphins, whose only victory was a 17-16 opening-week escape at the New England Patriots.

Moreover, each side’s offense and defense rank as a bottom-five NFL unit in terms of scoring and points allowed per game.

Dolphins QB Tua Tagovailoa is hoping to play after a three-week IR stint with a rib injury, and that should provide a boost for a Miami offense which ranks 30th in passing (191.4 yards per game).

But with rookie QB Trevor Lawrence getting his NFL legs under him and the Jags owning a significant advantage in the run game with stud second-year RB James Robinson (fourth in the league with 387 yards while averaging 5.8 yards per attempt), there’s no reason why Miami should be favored by anything more than a point or two.

Detroit Lions +3.5 (-110) vs. Cincinnati Bengals

Yep, we’re on each of the league’s winless teams this week.

Head coach Dan Campbell’s 0-5 Lions have been particularly feisty with a 3-2 record against the spread and losing two of their last three on 54-yard-plus field goals on the game’s final play.

Led by the QB Joe Burrow– WR Ja’Marr Chase LSU connection that’s already clicked for five TDs, the Bengals are 3-2. But they are also 2-3 ATS, now a road favorite for only the third time since 2018 and are in a prime look-past-the-winless-opponent spot with a game against the division-leading Baltimore Ravens looming next week.

Take the scrappy Lions and the field goal-plus.

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Tennessee Titans +5.5 (-110) vs. Buffalo Bills

Speaking of red-flag letdown spots, the 4-1 Bills are playing in their second straight primetime road game after notching a massive revenge 38-20 win at the host Kansas City Chiefs Sunday night.

The Tennessee defense, ranked 24th with 26.0 points allowed per game, is a clear concern facing Bills QB Josh Allen and the league’s highest-scoring offense (34.4 points). But if the 3-2 Titans can avoid turnovers (Buffalo has an NFL-most 15 takeaways) and get league rushing leader RB Derrick Henry (640 yards, 7 TDs) and the play-action game going with capable QB Ryan Tannehill, the hosts should be able to keep this Monday night matchup close.

If you hold off until closer to kickoff, you might even be able to catch more points with the Titans as the line has already gone up two full points after opening at Bills -3.5.

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Buffalo Bills at Kansas City Chiefs odds, picks and prediction

Analyzing Sunday Night Football’s Buffalo Bills at Kansas City Chiefs odds and lines, with expert NFL picks, predictions and best bets.

The Kansas City Chiefs (2-2) host the Buffalo Bills (3-1) for Sunday Night Football at Arrowhead Stadium. Kickoff is scheduled for 8:20 p.m. ET. Below, we look at the Bills vs. Chiefs odds and lines, and make our best NFL picks, predictions and bets.

The Bills have stampeded their last three opponents in the Houston Texans (40-0 in Week 4), Washington Football Team (43-21 in Week 3) and Miami Dolphins (35-0 in Week 2).

K.C. cruised past the Philadelphia Eagles 42-30 last week as a 7.5-point road favorite after back-to-back losses to the Los Angeles Chargers (30-24) and Baltimore Ravens (36-35).

The Chiefs beat the Bills twice last season: 26-17 in Week 6 as 5.5-point road favorites and 38-24 at home in the AFC Championship Game, covering as 3-point favorites.

Bills at Chiefs odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 10 a.m. ET.

Money line: Bills +115 (bet $100 to win $115) | Chiefs -140 (bet $140 to win $100)
Against the spread (ATS): Bills +2.5 (-105) | Chiefs -2.5 (-115)
Over/Under (O/U): 55.5 (O: -112 | U: -108)

Bills at Chiefs key injuries

Bills

LB Matt Milano (hamstring) questionable
RB Taiwan Jones (hamstring) questionable
DE A.J. Epenesa (foot) questionable

Chiefs

DT Chris Jones (wrist) questionable
CB Charvarius Ward (quadriceps) questionable
LB Willie Gay (toe) questionable

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Bills at Chiefs odds, lines, predictions and picks

Prediction

Chiefs 34, Bills 30

Money line

“LEAN” to the CHIEFS (-140) only because I could listen to laying the points instead, but K.C. is the right side.

By betting on the Chiefs we are backing one of the best quarterbacks and coaching staffs in the game as well as fading the public. According to Pregame.com, roughly 70% of the action was on Buffalo at the time of writing, which is making K.C. cheaper. There are a few reasons to fade the Bills as well.

First of all, Buffalo hasn’t faced a quality opponent. The Bills have played the easiest schedule in the NFL thus far while the Chiefs have played the third-toughest schedule. K.C. has underperformed its lofty expectations but losing at the Ravens on primetime and against a tough divisional opponent like the Chargers isn’t embarrassing.

Also, the possible absence of Milano is a major problem for the Bills. Milano is the highest graded linebacker by Pro Football Focus and its third-highest graded linebacker in pass coverage. If Milano is sidelined or compromised then TE Travis Kelce could tear this Buffalo defense apart.

The Bills have the best DVOA, according to Football Outsiders, because of their defense. But, they’ve played three of the worst offenses in the league. Offenses quarterbacked by Ben Roethlisberger, Jacoby Brissett, Taylor Heinicke and Davis Mills.

Against the spread

“LEAN” to the CHIEFS -2.5 (-115) based on the aforementioned analysis and because K.C.’s money line isn’t much more expensive.

Over/Under

PASS on the total because I could see both offenses trying to play keep away and eat the clock. K.C. should hide its terrible defense and Buffalo probably doesn’t want to get into a shootout with the Chiefs.

Furthermore, nearly 90% of the handle is on the Over but this total hasn’t moved much from the opener. It’s not very profitable following the crowd in sports betting.

That said, for me, it’s a little too “sharp” to back the Under. PASS.

Week 5 best bets

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Underdog corner: 3 best NFL ATS picks and predictions for Week 5

Assessing the NFL betting odds and lines for Week 5, with three predictions and picks for the best ATS underdog bets to make.

After a hot start, we cooled off here in Week 4, cashing in on only one of our three weekly selections. But, hey, 9-3 after four weeks? Certainly no hanging heads here. Below, we look at the top NFL underdog ATS picks and predictions of Week 5.

Also see: All Week 5 odds and lines

NFL underdog predictions: Week 5

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 4:15 p.m. ET.

Cincinnati Bengals +3.5 (-125) vs. Green Bay Packers

QB Aaron Rodgers and the Packers have bounced back nicely from their season-opening debacle against the New Orleans Saints, by reeling off three straight wins.

The Bengals are also 3-1 and have won with a promising mix of young offensive talent, led by second-year QB Joe Burrow and rookie WR Ja’Marr Chase, along with an improved and underrated defense.

That should be more than enough to at least keep it close — and possibly even win outright — at home against a banged-up Green Bay squad which likely will be without some key offensive linemen, its best pass rusher and top cornerback.

San Francisco 49ers +5.5 (-112) at Arizona Cardinals

QB Kyler Murray and the Cards are the league’s final unbeaten team and are coming off a huge 37-20 win over the previously undefeated Los Angeles Rams as 3.5-point road underdogs.

That, however, makes this a prime letdown spot for Arizona as it hosts an angry 49ers squad hitting the road off two straight stinging home setbacks.

Even though it likely will be rookie Trey Lance starting at QB for the Niners, they have had recent success in this NFC West series, winning three of the last four meetings.

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Buffalo Bills +2.5 (-102) at Kansas City Chiefs

K.C. is favored by less than a field goal at home Sunday night for the first time ever in a game QB Patrick Mahomes is slated to start.

That’s a giveaway right there that the wrong team might be favored in this rematch of last season’s AFC Championship Game won 38-24 by the Chiefs.

Both squads once again have top-three scoring offenses with top-level QBs, but the huge difference is defense as the Bills have surrendered the fewest points (44) and total yards (867) in the league while the Chiefs rank 31st in both categories, giving up 125 points and 1,751 yards.

With the spread under 3 points, take the Bills on the money line at +120 to earn a measure of revenge.

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Houston Texans at Buffalo Bills odds, picks and prediction

Analyzing Sunday’s Houston Texas at Buffalo Bills odds and lines, with expert NFL picks, predictions and best bets.

The Houston Texans (1-2) visit the Buffalo Bills (2-1) for a 1 p.m. ET kickoff at Highmark Stadium Sunday of Week 4. Below, we look at the Texans vs. Bills odds and lines, and make our best NFL picks, predictions and bets.

The Texans will look to even up their record against the mighty Bills offense following a Thursday Night Football loss to the Carolina Panthers in Week 3.

Bills QB Josh Allen had a rough start to the season with 3 touchdowns through 2 games but the fourth-year quarterback went for 4 touchdowns and 358 yards last week against the Washington Football Team. Without much of a run game, Allen will again be called on to make plays for Buffalo.

The Texans will look to WR Brandin Cooks and RB Mark Ingram for production. Rookie QB Davis Mills will again start with veteran QB Tyrod Taylor still injured. Mills had 168 yards and a touchdown against the Panthers.

Texans at Bills odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 4:40 p.m. ET.

Money line: Texans +850 (bet $100 to win $850) | Bills -1800 (bet $1,800 to win $100)
Against the spread (ATS): Texans +17.5 (-108) | Bills -17.5 (-112)
Over/Under (O/U): 46.5 (O: -117 | U: -103)

Texans at Bills key injuries

Texans

WR Danny Amendola (thigh) out
DB Terrance Mitchell (concussion, illness) questionable
RB Scottie Phillips (illness) out
LB Garrett Wallow (illness) questionable

Bills

S Jordan Poyer (ankle) out
OL Jon Feliciano (illness) out
CB Taron Johnson (groin) questionable
DE Efe Obaba (ankle) questionable

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Texans at Bills odds, lines, predictions and picks

Prediction

Bills 31, Texans 16

Money line

PASS on the money line. While Buffalo is at home and should come out on top, there’s no doubt that passing on a -1800 line is the right move.

There’s no reason to bet 18 times your potential return. All these players are paid to play football at a high level and upsets happen.

Against the spread

“LEAN” to the TEXANS +17.5 (-108) as the better value.

Mills, once he got comfortable in the offense and playing at the NFL level last week, started to move the ball. With veterans in the backfield and out wide, the Texans should be able to at least push the Bills early.

The Texans haven’t lost by more than 15 points, even while playing tough opponents in the Panthers and Cleveland Browns. With Poyer’s absence for the Bills the underdogs covering seems likely.

Over/Under

BET on the OVER 46.5 (-117) as Allen is starting to heat up.

With his struggles, the Bills went Over the projected line just once through three games. The Texans hit the Over in two of three contests.

Expect a big day from Allen against a Texans defense that gave up over 300 yards to Panthers QB Sam Darnold last week.

Mills is also getting more comfortable in the pocket, which may allow the Texans to consistently get in scoring position.

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Washington Football Team at Buffalo Bills odds, picks and prediction

Analyzing the Washington Football Team at Buffalo Bills Week 3 odds and lines, with expert NFL picks, predictions and best bets.

The Washington Football Team (1-1) stop by Highmark Stadium Sunday for a 1 p.m. ET game against the Buffalo Bills (1-1) in Week 3. Below, we look at the Washington vs. Bills odds and lines, and make our best NFL picks, predictions and bets.

Washington beat the New York Giants 30-29 with a game-winning field goal as tied expired on Thursday Night Football in Week 2. However, Washington failed to cover as 4-point home favorites against the Giants and lost outright and against the spread at home to the Los Angeles Chargers in Week 1.

Buffalo bounced back from a 23-16 upset by the Pittsburgh Steelers in its opener as 6.5-point home favorites by drubbing the Miami Dolphins 35-0 in Week 2 as 3.5-point road favorites.

Washington at Bills odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 11:37 a.m. ET.

Money line: Washington +265 (bet $100 to win $265) | Bills -350 (bet $350 to win $100)
Against the spread (ATS): Washington +7.5 (-120) | Bills -7.5 (-105)
Over/Under (O/U): 45.5 (O: -108 | U: -112)

Washington at Bills key injuries

Washington

No notable injuries.

Bills

CB Levi Wallace (knee) questionable

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Washington at Bills odds, lines, predictions and picks

Prediction

Bills 26, Washington 21

Money line

PASS with a heavy “lean” toward Washington (+265) because Washington plus the points is one of my favorite bets of the NFL Week 3 slate and typically I like sprinkling on an underdog’s money line when betting them to cover.

However, this is Washington QB Taylor Heinicke‘s first career road start and perhaps the Bills are a sleeping tiger right now. It’s hard to argue that Buffalo should be laying more than a touchdown in this spot, but I think the Bills will most likely pull out a win.

Against the spread

GIMME WASHINGTON +7.5 (-120) for 1.25 units. This is my favorite side of this Week 3 slate and you can listen to why I like Washington in further detail on this week’s Bet Slippin’ Podcast.

However, the gist of my analysis is that Buffalo hasn’t looked good enough offensively to be this big of a favorite. Josh Allen ranks 24th in EPA plus completion percentage over expectation composite, 28th in DVOA, 22nd in QBR and 28th by PFF. Granted, Buffalo’s first two opponents were tough defenses but Washington is as talented defensively as either Pittsburgh or Miami.

We have a significant “reverse line move” (RLM) in the betting market. More than three-fourths of the cash and nearly 90% of the action is on Buffalo laying the points according to Pregame.com at the time of writing, but the Bills opened as a 9-point consensus favorite and have come down to the current price despite the one-sided action.

Over/Under

PASS on the total because it could go either way in the Washington-Bills game. Both teams play at a top-eight neutral situation pace (seconds per play). On the other hand, we have RLM in the total market also as far more action is on the Over but this total has come down from the 47-point opener.

Furthermore, Buffalo looks less explosive offensively and Washington looks less formidable defensively than expected through two weeks. However, the Bills have been awesome defensively thus far and Washington has a ton of weapons for Heinicke to work with.

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First look: Buffalo Bills at Miami Dolphins odds and lines

Looking at Sunday’s Buffalo Bills at Miami Dolphins Week 2 NFL odds, lines and trends. Here’s what you need to know.

The Buffalo Bills (0-1) and Miami Dolphins (1-0) meet Sunday in Week 2 at Hard Rock Stadium in Miami Gardens, Fla. Kickoff is scheduled for 1 p.m. ET. Below, we look at the Bills vs. Dolphins odds and lines; check back for our NFL picks and predictions.

The Bills were unable to generate much offense in a 23-16 loss at home to the Pittsburgh Steelers. Buffalo led 10-0 at halftime, but Pittsburgh rallied for a 13-10 lead early in the fourth quarter and pretty much put it away with a blocked punt for touchdown.

The Dolphins went to New England and spoiled the debut of rookie QB Mac Jones, winning 17-16 after pouncing on a fumble with the home team driving. Miami was the only AFC East team to win in Week 1.

Bills at Dolphins odds, spread and line

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 7:54 a.m. ET.

Money line: Bills -180 (bet $180 to win $100) | Dolphins +145 (bet $100 to win $145)
Against the spread (ATS): Bills -3.5, -107 (bet $107 to win $100) | Dolphins +3.5, -115 (bet $115 to win $100)
Total (O/U): 47.5, Over -112 (bet $112 to win $100) | Under -108 (bet $108 to win $100)

2021 betting stats:

ML: Bills 0-1 | Dolphins 1-0
ATS: Bills 0-1 | Dolphins 1-0
O/U: Bills 0-1 | Dolphins 0-1

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Bills at Dolphins head-to-head

The Bills trounced the visiting Dolphins 56-26 in Week 17 last season as 3.5-point underdogs, taking care of the Over on their own. Buffalo also won in Miami 31-28, but the Dolphins cashed as 2.5-point underdogs as the Over hit.

Buffalo has won five straight in this series, going 3-2 ATS. The Over is a perfect 5-0 in the previous five meetings, too. The last time the Dolphins protected their home field against the Bills was a 21-17 win Dec. 2, 2018.

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Pittsburgh Steelers at Buffalo Bills odds, picks and prediction

Analyzing the Pittsburgh Steelers at Buffalo Bills Week 1 odds and lines, with expert NFL picks, predictions and best bets.

Once again led by QB Ben Roethlisberger, the Pittsburgh Steelers will open the season on the road against the Buffalo Bills, who are projected to be one of the best teams in the AFC. Kickoff is set for 1 p.m. ET Sunday at Highmark Stadium. Below, we look at the Steelers vs. Bills odds and lines, and make our best NFL picks, predictions and bets.

After starting last season 11-0, the Steelers lost five of their last six games, including a postseason loss to the Cleveland Browns in the wild-card round. Now with RB Najee Harris in the backfield and WR JuJu Smith-Schuster back on a one-year deal, Pittsburgh has the playmakers to once again reach the playoffs this season.

QB Josh Allen is the catalyst that makes the Bills go and he’ll look to follow up a career year in 2020 with a potential MVP season this year. WR Stefon Diggs remains the top wideout, while RBs Zack Moss and Devin Singletary will split time in the backfield. The defense will look to improve, too, after finishing 16th in scoring last year.

Also see: NFL team win totals

Steelers at Bills odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 5:15 p.m. ET.

Money line: Steelers +220 (bet $100 to win $220) | Bills -280 (bet $280 to win $100)
Against the spread (ATS): Steelers +6.5 (-110) | Bills -6.5 (-110)
Over/Under (O/U): 47.5 (O: -115 | U: -105)

Steelers at Bills key injuries

Steelers

LB Alex Hightower (groin) questionable

Bills

DT Star Lotulelei (calf) out
WR Emmanuel Sanders (foot) questionable

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Steelers at Bills odds, lines, predictions and picks

Prediction

Bills 27, Steelers 17

Money line

The Steelers have the edge on defense, but this game will come down to quarterback play and Buffalo has a huge advantage in that department. Allen will do enough to help the Bills win this game despite a decent effort from Pittsburgh’s defense.

The Steelers don’t look any better now than they did at the end of last season and Roethlisberger is another year older. Give me the BILLS (-280) with a small wager on the money line.

Against the spread

The Bills covered the spread nine times across their last 11 games last season. The Steelers, on the other hand, covered only twice in their last seven games. The 6.5-point spread is larger than most games in Week 1, but the Bills are one of the best teams in football on paper.

Take the BILLS -6.5 (-110) to cover and win by at least a touchdown.

Over/Under

The Bills won last season’s head-to-head meeting 26-15. The Pittsburgh defense should have one of the best pass rushes in the game once again, led by OLB T.J. Watt, which could give the Bills some trouble.

On the other side, I expect the Bills secondary to pick off a couple of passes to limit Pittsburgh’s offense. Bet the UNDER 47.5 (-105).

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com. Please gamble responsibly.

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Green Bay Packers at Buffalo Bills odds, picks and prediction

Analyzing Saturday’s Green Bay Packers at Buffalo Bills preseason Week 3 matchup, with NFL odds, lines, picks, predictions and best bets.

The Green Bay Packers (0-2) meet the Buffalo Bills (2-0) Saturday for a 1 p.m. ET kickoff at Ralph Wilson Stadium. Below, we look at the Packers vs. Bills odds and lines, and make our best NFL picks, predictions and bets.

The Packers have struggled in the preseason falling to the Houston Texans by a 26-7 score Aug. 14, and 23-14 against the New York Jets Saturday. Green Bay posted just 143 passing yards and 135 rushing yards against the Jets.

The Bills rolled up 41 points in Chicago against the Bears last Saturday, the most points scored by any team so far this preseason. They also picked up a 16-15 win Aug. 13, on the road against the Detroit Lions.

Packers at Bills odds, spread and lines

Odds via Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 7:40 a.m. ET.

Money line: Packers +280 (bet $100 to win $280) | Bills -370 (bet $370 to win $100)
Against the spread/ATS: Packers +8.5 (-112) | Bills -8.5 (-108)
Total: 34.5 (Over: -112 | Under: -108)

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Packers at Bills odds, lines, picks and predictions

Prediction

Bills 24, Packers 13

Money line

The Bills (-370) will cost you nearly four times your potential return, and that’s not a good bet in the preseason, or otherwise.

AVOID and play the spread instead.

Against the spread

The BILLS -8.5 (-108) are likely to use QB Josh Allen very little, but backup QB Mitchell Trubisky shows how much depth Buffalo has at the position. Allen didn’t even play in the team’s 41-15 blowout win last weekend. Whether or not Allen plays, take the Bills.

QB Aaron Rodgers isn’t likely to play for the Packers, and if he does, it will be a cameo. QB Jordan Love (shoulder) is out with a shoulder, so the Pack doesn’t have a ton of depth at the position at the moment.

Over/Under

OVER 34.5 (-112) is worth a look, as the Bills offense has been on point with or without Allen. The Packers have struggled to put up points, as Rodgers has sat and Love has been injured, but the reserves could strike late to push this one over the top.

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com. Please gamble responsibly.

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