Seattle Seahawks at Detroit Lions odds, picks and predictions

Analyzing Monday’s Seattle Seahawks at Detroit Lions odds and lines, with expert NFL picks and predictions.

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The Seattle Seahawks (3-0) and Detroit Lions (2-1) meet Monday with Kickoff from Ford Field is scheduled for 8:15 p.m. ET (ABC/ESPN+). Let’s analyze BetMGM Sportsbook’s NFL odds around the Seahawks vs. Lions odds, and make our expert NFL picks and predictions..

The Seahawks stayed unbeaten with a 24-3 win over the Miami Dolphins in Week 3, covering the 4-point spread as the Under (42) hit. RB Zach Charbonnet stepped up with 91 rushing yards and 2 TDs, while WR DK Metcalf recorded his 2nd straight 100-yard game and had a TD.

The Lions secured a 20-13 road win in Week 3 against the Arizona Cardinals, covering as 3-point favorites and hitting the Under 51 total. RBs David Montgomery and Jahmyr Gibbs combined for 188 rushing yards and a TD, while WR Amon-Ra St. Brown had 75 receiving yards and caught his 1st TD of the season.

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Seahawks at Lions odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Sunday at 3:46 p.m. ET.

  • Moneyline (ML): Seahawks +165 (bet $100 to win $165) | Lions -200 (bet $200 to win $100)
  • Against the spread (ATS): Seahawks +4 (-110) | Lions -4 (-110)
  • Over/Under (O/U): 46.5 (O: -110 | U: -110)

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Seahawks at Lions key injuries

Seahawks

  • DT Byron Murphy II (hamstring) out
  • DE Leonard Williams (ribs) out
  • LB Boye Mafe (knee) out
  • LB Uchenna Nwosu (knee) out
  • LB Jerome Baker (hamstring) questionable

Lions

  • C Frank Ragnow (pectoral) out
  • CB Ennis Rakestraw Jr. (hamstring) questionable

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Seahawks at Lions picks and predictions

Prediction

Lions 24, Seahawks 21

Moneyline

PASS.

This will be a tight game that will likely come down to a late field goal to win it. It’ll come down to who gets the ball last which is why I’m going to avoid the moneyline and look to the spread.

Against the spread

BET SEAHAWKS +4 (-110).

Coach Mike Macdonald has Seattle playing like a complete team, ranking 2nd in total DVOA, with balanced top-10 rankings on offense and defense. Despite facing manageable opponents so far (the Denver Broncos, New England Patriots and Miami), they’ve looked more refined each week, and their undefeated start speaks volumes. Their passing game, led by dynamic receivers, poses a tough challenge for a Detroit secondary that has allowed a 67% completion rate to opposing QBs.

Detroit, on the other hand, hasn’t quite lived up to the early season hype. While they are still a formidable team, they’ve struggled with turnovers and finishing drives, and even top offensive coordinator Ben Johnson has yet to find his rhythm this season. Their inconsistent offense has kept games closer than expected, as seen in tight matchups with the LA Rams and Cardinals, and a loss to the Tampa Bay Buccaneers at home.

Seattle’s defense has shown resilience and promise, and their offense should be able to keep pace against a Lions squad that’s yet to put it all together. With Detroit’s issues and Seattle’s steady rise, taking the Seahawks to cover the spread makes sense in this matchup.

Over/Under

PASS.

There’s no strong edge here—recent trends are mixed. The Over has only hit in 5 of their last 9 meetings, while Seattle is 5-4-1 against the Over and Detroit is 5-5. Both teams combine for an average of 45 points per game, which is almost right on the line. With no clear trends or consistent offensive output pointing either way, it’s best to avoid this bet altogether.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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