San Francisco 49ers favored at home against Philadelphia Eagles in Week 4

The San Francisco 49ers are betting favorites at home in their Week 4 game against the Philadelphia Eagles on Sunday Night Football.

The San Francisco 49ers (2-1) return home after back-to-back games in New York to take on the Philadelphia Eagles (0-2-1) in Week 4. They kick off on Sunday Night Football at 8:20 p.m. ET at Levi’s Stadium in Santa Clara. Below, we take a look at the early Week 4 betting odds and lines at BetMGM Sportsbook.

The 49ers won their second game in a row at MetLife Stadium, beating the New York Giants 36-9 in Week 3. They played without most of their key offensive starters and some defensive players as well, as they have been hit big by injuries. Backup QB Nick Mullens threw for 343 yards and a touchdown, and rookie WR Brandon Aiyuk scored his first NFL touchdown (as a rusher). They held the Giants to 231 yards of offense and intercepted QB Daniel Jones once.

The Eagles are coming off a 23-23 tie with the Cincinnati Bengals. The Eagles rallied to tie the game with a rushing touchdown from QB Carson Wentz with 21 seconds left in regulation. Neither team could score in overtime. Wentz was picked off twice in the game.

Eagles at 49ers betting odds, spread and line

Odds via BetMGM; last updated Monday at 1:40 p.m. ET. 

  • Money line: 49ers -278 (bet $278 to win $100) / Eagles +225 (bet $100 to win $225) | Bet now
  • Against the spread: 49ers -6.5, -110 (bet $110 to win $100) / Eagles +6.5, -110 (bet $110 to win $100) | Bet now
  • Total: 44.5, Over -110 (bet $110 to win $100) / Under -110 (bet $110 to win $100) | Bet now

New to NFL betting?

At -278 odds, the Seahawks have an implied 73.54% chance of beating the Dolphins in Week 4, or 50/139 fractional odds. San Francisco must win by at least a touchdown for the 49ers’ -6.5 (-110) ATS ticket to cash.

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The underdog Eagles, at +225 odds, have an implied 30.77% chance of winning, or 9/4 fractional odds. If Philadelphia wins, or if it loses by fewer than seven points, an Eagles +6.5 (-110) bet wins.

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