New York Giants at Tennessee Titans odds, picks and predictions

The New York Giants head to Nashville to take on the Tennessee Titans Sunday. The game is scheduled for a 4:25 p.m. ET kickoff (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Giants at Titans odds, and make our expert NFL picks and predictions.

The Giants are coming off of a 4-13 season while losing their final 6 games. Sunday will be the 1st game for new coach, Brian Dabol, new offensive coordinator Mike Kafka, and a multitude of new faces on the field including OG Mark Glowinski and backup QB Tyrod Taylor.

The Giants will look for stronger campaigns this season for now-healthy RB Saquon Barkley and QB Daniel Jones, who has taking a liking to coach Dabol.

The Titans are reigning AFC South champions behind a 12-5 regular-season record. RB Derrick Henry will look to pick up where he left off midseason after being sidelined with a broken foot in Week 8.

QB Ryan Tannehill will look for success with new faces on offense, including key addition WR Robert Woods. For the most part, this is an experienced group with aspirations higher than just making the playoffs.

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Giants at Titans odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:50 a.m. ET.

Money line (ML): Giants +205 (bet $100 to win $205) | Titans -250 (bet $250 to win $100)
Against the spread (ATS): Giants +5.5 (-108) | Titans -5.5 (-112)
Over/Under (O/U): 43.5 (O: -115 | U: -105)

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Giants at Titans key injuries

Giants

OLB Azeez Ojulari (calf) doubtful
OLB Kayvon Thibodeaux (knee) doubtful

Titans

DB Lonnie Johnson (groin) out

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Giants at Titans picks and predictions

Prediction

Titans 24, Giants 17

Money line

PASS.

The risk is not worth the reward for this matchup. A -250 favorite, even at home, isn’t ideal for a bettor.

Against the spread

BET TITANS -5.5 (-112).

With an inexperienced Giants team that still has many questions to be answered regarding expectations, Henry will be too much to handle for the Giants defense.

Expect Henry to have a massive game and Woods to bring his Super Bowl experience and fit right in with a coach Mike Vrabel-led offense. The difference in coaching pedigree is also something to note.

The Giants have been horrific against the spread recently. They are 0-6 ATS in their last 6 games, 0-6 ATS in their last 6 games as road underdogs and 0-5 ATS in their last 5 Week 1 games.

Over/Under

LEAN UNDER 43.5 (-105).

Between Henry for the Titans and Barkley for the Giants, this matchup could turn out to be a run-heavy game.

Expect the Titans to get out to an early lead, causing them to control possession and forcing Jones and the Giants to play from behind. Jones is also a good runner, so don’t be shocked to see him keep it on the ground.

The Under is 4-0 in the Titans’ last 4 games as home favorites and 5-1 in the Titans’ last 6 games overall. Furthermore, the Under is 5-1 in the Giants’ last 6 games in Week 1 and is 19-7-1 in the Giants’ last 27 games as underdogs.

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