New York Giants at Arizona Cardinals odds, picks and predictions

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The New York Giants (0-1) are on the road in Week 2 to take on the Arizona Cardinals (0-1) in their 2023 home opener Sunday. Kickoff from State Farm Stadium is 4:05 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Giants vs. Cardinals odds, and make our expert NFL picks and predictions.

The Giants opened the season by getting shut out 40-0 at home by the Dallas Cowboys. They turned the ball over 3 times (2 interceptions, 1 lost fumble) and QB Daniel Jones was sacked 7 times and fumbled twice (although both were recovered).

The Cardinals lost 20-16 on the road to the Washington Commanders but covered as 7-point underdogs. Arizona had 6 sacks and 3 takeaways but QB Josh Dobbs lost 2 fumbles that resulted in 10 Washington points.

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Giants at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:05 p.m. ET.

Moneyline (ML): Giants -210 (bet $210 to win $100) | Cardinals +170 (bet $100 to win $170)
Against the spread (ATS): Giants -4 (-110) | Cardinals +4 (-110)
Over/Under (O/U): 39.5 (O: -110 | U: -110)

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Giants at Cardinals key injuries

Giants

LB Azeez Ojulari (hamstring) doubtful
WR Wan’Dale Robinson (knee) doubtful
OL Andrew Thomas (hamstring) questionable

Cardinals

S Budda Baker (hamstring) questionable
DL L.J. Collier (biceps) out
DL Leki Fotu (shoulder) questionable
LB Josh Woods (ankle) out

Giants at Cardinals picks and predictions

Prediction

Cardinals 22, Giants 20

Moneyline

The Cardinals got almost nothing offensively in Week 1, netting only 210 total yards (and 60 of those came on 2 plays in their 1st possession), and the defense scored the only touchdown. However, the Giants’ defense isn’t as good as the Commanders’.

The problems of protection that New York had last week should again be a problem against Arizona. The Cards had 6 sacks last week and have sacked Jones 14 times in his 2 career starts vs. them.

BET CARDINALS (+170).

Against the spread

When the line opened at Giants -5.5, this was an easy pick.

The Cardinals proved to be tougher than expectations had them while the Giants — a playoff team last year — looked exceptionally bad in Week 1.

This is a home opener for Arizona with a new coaching staff, so there will be some extra energy in the stadium. There will be plenty of Giants fans as well, but the Cardinals should be able to do a little more offensively than they did in Week 1.

Expect a close game at a minimum and take the Cardinals to cover if you can’t quite take them to win outright.

BET CARDINALS +4 (-110).

Over/Under

Neither team’s game hit the Over in Week 1 but this game’s 39.5-point projected total is low.

The Cardinals and Commanders had 36 total points and Arizona didn’t score an offensive touchdown.

New York’s offense is probably better than Washington’s. New York’s defense isn’t as good as Washington’s, so Arizona should be able to do a little better.

I lean OVER 39.5 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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