Indianapolis Colts at Pittsburgh Steelers odds, picks and prediction

Previewing the Indianapolis Colts at Pittsburgh Steelers Week 16 betting odds and lines, with NFL betting picks, tips and predictions.

The Indianapolis Colts (10-4) visit the Pittsburgh Steelers (11-3) Sunday for a 1 p.m. ET kickoff at Heinz Field. Below, we preview the Colts-Steelers betting odds and lines and make our NFL picks and predictions.

Colts at Steelers: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 2:20 p.m. ET.

  • Money line: Colts -105 (bet $105 to win $100) | Steelers -110 (bet $110 to win $100)
  • Against the spread/ATS: Colts +1 (-115) | Steelers -1 (-105)
  • Over/Under: 42.5 (O: -115 | U: -105)

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Special New Jersey and West Virginia Betting Promotion

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Colts at Steelers: Game notes

  • The Steelers hit rock bottom last Monday night, losing at the last-place Cincinnati Bengals 27-17. Previously, they lost back-to-back games to the Washington Football Team and Buffalo Bills, two teams technically in first place in their respective divisions. It was alarming after an 11-0 start but still not the end of the world. A 10-point loss in Cincinnati against the cellar-dwelling Bengals in front of a national audience was not a good look.
  • Pittsburgh posted an 8-3 ATS mark across the first 11 games, all victories, but it has failed to cover in each of its last three games during the 0-3 SU skid. The Steelers have had a power outage on offense, averaging just 16.3 PPG during the three-game slide.
  • The Colts picked up a 27-20 victory against the Houston Texans, narrowly missing a cover as 7.5-point favorites. They enter on a three-game win streak, averaging 32.3 PPG while yielding just 22.3 PPG. This will be Indy’s fourth game against an AFC North team – it is 1-2 SU/0-3 ATS in those contests.
  • Indianapolis ranks ninth in the NFL with 260.8 passing yards per game, and it is also ninth in the league with 28.5 PPG. Defensively it has been very good, ranking seventh with 334.1 total YPG allowed, and just 98.1 rushing YPG. It is allowing just 22.9 PPG to rank 11th.
  • The Steelers allowed just 11.5 PPG in four wins from Week 9 through 12, but they have coughed up 25.3 PPG during their three-game losing skid.

Colts at Steelers: Key injuries

Colts

  • OT Anthony Castonzo (knee, ankle) out
  • DE Al-Quadin Muhammad (ankle) questionable
  • RT Braden Smith (COVID-19 list) out

Steelers

  • LB Marcus Allen (stinger) questionable
  • PK Chris Boswell (groin) questionable
  • RB Anthony McFarland Jr. (illness) questionable

Colts at Steelers: Odds, betting lines, predictions and picks

Prediction

Colts 26, Steelers 20

Money line (?)

The COLTS (-105) are worth playing straight-up. Until the struggling Steelers can pull out of their nosedive, you need to continue to fade them. They’re showing no signs of doing so, and things are actually getting worse.

Against the spread (?)

The COLTS +1 (-115) haven’t covered in three straight outings since Week 2 through 4, and they have yet to piece together a four-game win streak this season. But they’re the play here, as the Steelers are ice cold and showing no signs of life on offense recently. Indy is also 4-0 ATS in its past four on the road and 15-6 ATS in the past 21 against winning teams.

While Indy is just 1-4 ATS in the past five trips to Pittsburgh and 1-4 ATS in the past five in this series, a lot of the personnel has changed from those previous outings and there’s not much to glean from those trends. The in-season trends are the ones to lean upon more.

Over/Under (?)

OVER 42.5 (-115) is worth a small-unit play. Again, the series trends suggest an Over, going 4-0 in the past four meetings in Pittsburgh. But again, the teams have turned over their rosters plenty since the most recent meeting. More importantly, the Over is 7-3 in Indy’s past 10 games this season, and 9-3 in its past 12 as a road favorite while cashing in four straight against winning sides.

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