The Indianapolis Colts (2-2) and Tennessee Titans (2-2) released their lists of inactive players ahead of the Week 5 matchup at Lucas Oil Stadium.
Here are the inactive players for the Colts in Week 5:
| Name | Position | Injury |
| Bernhard Raimann | OT | Concussion |
| Kwity Paye | DE | Concussion |
| Shaquille Leonard | LB | Groin |
| Sam Ehlinger | QB | — |
| Will Mallory | TE | — |
Notes
- RB Jonathan Taylor is officially active for the first time this season.
- QB Sam Ehlinger will serve as the emergency third quarterback.
- With Bernhard Raimann out, rookie Blake Freeland will serve as the starting left tackle.
- Rookie DT Adetomiwa Adebawore is active for the second consecutive game.
Here are the inactives for the Titans in Week 5:
| Name | Position | Injury |
| Treylon Burks | WR | Knee |
| Luke Gifford | LB | Hamstring |
| Teair Tart | DT | Toe |
| Will Levis | QB | — |
| Caleb Murphy | LB | — |
| Jaelyn Duncan | OT | — |
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