The Cleveland Guardians (80-67) and Chicago White Sox (76-71) open a 3-game AL Central series Tuesday. First pitch from Guaranteed Rate Field is at 8:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Guardians vs. White Sox odds with MLB picks and predictions.
Season series: Cleveland leads 9-7
The Guardians are coming off a 6-2 homestand that included a Thursday loss to this ChiSox squad. Cleveland went 6-1 in its first 7 games against Chicago but is just 3-6 against the Sox since.
The mercurial White Sox are back at home after a 3-1 road trip. After the all-star break, strong pitching got Chicago within a game of 1st place in the AL Central by Aug. 17.
The Sox then suffered through a 2-10 stretch in late August, however, Chicago has gone 13-5 since Aug. 31. The Pale Hose have outscored foes by 2 1/2 runs per game (5.67 runs per game vs. 3.17 allowed) across that span.
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Guardians at White Sox projected starters
RHP Aaron Civale vs. RHP Dylan Cease
Civale (2-6, 5.40 ERA) is tabbed for his 17th start of the season. He has a 1.31 WHIP, 2.4 BB/9 and 9.0 K/9 through 75 IP.
- Coming off the 15-day IL (forearm) for this turn; last pitched Aug. 28
- Owns a 6.43 ERA and 1.41 WHIP on the road
Cease (14-7, 2.16 ERA) makes his 30th start. He has a 1.08 WHIP, 3.7 BB/9 and 11.5 K/9 through 167 IP.
- Sports the AL’s 3rd-best ERA
- Has benefited from a .263 batting average on balls in play
Guardians at White Sox odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:43 a.m. ET.
- Money line: Guardians +140 (bet $100 to win $140) | White Sox -175 (bet $175 to win $100)
- Run line (RL)/Against the spread (ATS): Guardians +1.5 (-155) | White Sox -1.5 (+125)
- Over/Under (O/U): 7.5 (O: +105 | U: -130)
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Guardians at White Sox picks and predictions
Prediction
White Sox 6, Guardians 3
Money line
PASS. Look to the Run Line for the better play in this series opener.
Run line/Against the spread
The recent run differential for the White Sox is compelling, and Chicago has played Cleveland tough.
The Pale Hose opened the 2nd half with back-to-back home losses against this Cleveland club. Beginning with wins over the Guardians the next 2 days, Chicago is 16-10 over its last 26 games at home.
TAKE CHICAGO -1.5 (+125). Tag this play as a partial-unit one.
Over/Under
There is some gray area presented by Civale returning from injury (after an ineffective rehab outing in the minors). Cease has gotten by with a .162 BABIP over his last 5 starts. And both bullpens sport some luck factors of late that would support some regression toward more traffic on the bags and more runs crossing the plate.
However, both offenses profile as being slightly overcooked, so it’s not wise to lean too heavily into an Over when they are on the same diamond. So, consider a partial-unit play on the OVER 7.5 (+105).
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