NFL Picks and Predictions – Page 152

First look: Cincinnati Bengals at New Orleans Saints odds and lines

Looking at Sunday’s Cincinnati Bengals at New Orleans Saints Week 6 NFL odds, lines and trends. Here’s what you need to know.

The Cincinnati Bengals (2-3) face the New Orleans Saints (2-3) Sunday in Week 6. Kickoff from Caesars Superdome is at 1 p.m. ET (CBS). Below, we look at Bengals vs. Saints odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

Also see: All Week 6 odds and lines

The Bengals are off to a slow start this season after advancing to the Super Bowl last year. Despite addressing the offensive line in the offseason, QB Joe Burrow has been sacked 18 times in the first 5 weeks. Cincinnati lost 19-17 at the Baltimore Ravens in Week 5.

The Saints picked up their second victory with a 39-32 victory over the Seattle Seahawks Sunday. RB Alvin Kamara returned from injury and recorded 194 scrimmage yards on 29 touches against the Seahawks.

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Bengals at Saints odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 9:15 a.m. ET.

Moneyline (ML): Bengals -115 (bet $115 to win $100) | Saints -103 (bet $103 to win $100)
Against the spread (ATS): Bengals +0.5 (-115) | Saints -0.5 (-105)
Over/Under (O/U): 43.5 (O: -117 | U: -103)

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2022 betting stats

ML: Bengals 2-3 | Saints 2-3
ATS: Bengals 3-2 | Saints 2-3
O/U: Bengals 0-5 | Saints 3-2

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Bengals vs. Saints head-to-head

This Sunday will be just the 15th all-time meeting between the Bengals and the Saints. Cincinnati and New Orleans are tied with 7 wins apiece.

New Orleans came away with a 51-14 when the Bengals and Saints last met in 2018. However, the Bengals have won 4 of the last 6 games in the series, including 2 games in New Orleans.

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First look: Jacksonville Jaguars at Indianapolis Colts odds and lines

Looking at Sunday’s Jacksonville Jaguars at Indianapolis Colts Week 6 NFL odds, lines and trends. Here’s what you need to know.

The Jacksonville Jaguars (2-3) travel to take on the Indianapolis Colts (2-2-1) Sunday in Week 6. Kickoff from Lucas Oil Stadium 1 p.m. ET (CBS). Below, we look at Jaguars vs. Colts odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The Jaguars got off to a 2-1 start to the season before losing their last 2 games to the Philadelphia Eagles (29-21) and the Houston Texans (13-6). QB Trevor Lawrence has turned the ball over a combined 7 times in the last 2 weeks and will look to do a better job protecting the ball Sunday.

The Colts were able to squeak out a narrow 12-9 victory in Week 5 against the Denver Broncos in a game where both offenses were unable to get much going. Indianapolis will also need QB Matt Ryan to protect the football as he’s thrown 7 interceptions and fumbled the ball 11 times (3 lost).

Also see: All Week 6 odds and lines

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Jaguars at Colts odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 8:50 a.m. ET.

Moneyline (ML): Jaguars +105 (bet $100 to win $105) | Colts -125 (bet $125 to win $100)
Against the spread (ATS): Jaguars +2.5 (-112) | Colts -2.5 (-108)
Over/Under (O/U): 41.5 (O: -105 | U: -115)

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2022 betting stats

ML: Jaguars 2-3 | Colts 2-2-1
ATS: Jaguars 2-3 | Colts 2-3
O/U: Jaguars 3-2 | Colts 0-5

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Jaguars vs. Colts head-to-head

This Sunday’s showdown will be the 44th meeting between the Jaguars and the Colts. Indianapolis has a 26-17 edge in the all-time matchup.

The Jaguars have had more success recently, though, winning 4 of the last 6 games in the series. Jacksonville has won 2 straight against Indianapolis and shut out the Colts 24-0 at home in Week 2.

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First look: Arizona Cardinals at Seattle Seahawks odds and lines

Looking at Sunday’s Arizona Cardinals at Seattle Seahawks Week 6 NFL odds, lines and trends. Here’s what you need to know.

The Arizona Cardinals (2-3) are on the road in Week 6 to face the Seattle Seahawks (2-3) in an NFC West division game. Kickoff is Sunday at 4:05 p.m. ET (FOX). Below, we look at Cardinals vs. Seahawks odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The Cardinals are coming off a tough 20-17 loss to the undefeated Philadelphia Eagles Sunday. K Matt Ammendola missed a 43-yard field goal with 22 seconds remaining in the game that would have tied the game and sent it to overtime. The Cardinals are 2-0 on the road, 0-3 at home this season and have lost 8 straight games at State Farm Stadium.

The Seahawks continued their offensive success but lost to the New Orleans Saints 39-32 on the road in Week 5. QB Geno Smith passed for 268 yards and 3 touchdowns in the loss, but the defense allowed 235 rushing yards, as Taysom Hill rushed for 112 yards and 3 touchdowns, and RB Alvin Kamara added 194 total yards from scrimmage.

Also see: All Week 6 odds and lines

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Cardinals at Seahawks odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 7:50 a.m. ET.

Moneyline (ML): Cardinals -140 (bet $140 to win $100) | Seahawks +117 (bet $100 to win $117)
Against the spread (ATS): Cardinals -2.5 (-117) | Seahawks +2.5 (-103)
Over/Under (O/U): 51.5 (O: -105 | U: -115)

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2022 betting stats

ML: Cardinals 2-3 | Seahawks 2-3
ATS: Cardinals 3-2 | Seahawks 2-3
O/U: Cardinals 1-3-1 | Seahawks 3-2

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Cardinals vs. Seahawks head-to-head

This will be the 47th time the teams have played. The Seahawks lead the all-time series 23-22-1. Since realignment in 2002 when they both joined the NFC West, the Seahawks lead 22-17-1.

They have split the season series each of the last 3 years.

The Cardinals are 6-2 in Seattle in the last 8 meetings there.

Cardinals QB Kyler Murray is 2-3 in 5 career starts against Seattle.

Smith has never started a game in his career against the Cardinals.

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First look: San Francisco 49ers at Atlanta Falcons odds and lines

Looking at Sunday’s San Francisco 49ers at Atlanta Falcons Week 6 NFL odds, lines and trends. Here’s what you need to know.

The San Francisco 49ers (3-2) are on the road in Week 6 to face the Atlanta Falcons (2-3). Kickoff is Sunday at 1 p.m. ET at Mercedes Benz Stadium (FOX). Below, we look at 49ers vs. Falcons odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The 49ers improved to 3-2 in Week 5 with a 37-15 win over the Carolina Panthers. QB Jimmy Garoppolo passed for 254 yards and 2 touchdowns and RB Jeff Wilson had 120 rushing yards and a touchdown on 17 carries. The 49ers are in first place in the NFC West.

The Falcons managed only 261 yards of total offense against the Tampa Bay Buccaneers. They fell behind 21-0 and rallied for 15 fourth-quarter points, but the Bucs were able run out the clock after the Falcons scored for the last time.

Also see: All Week 6 odds and lines

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49ers at Falcons odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 7:40 a.m. ET.

Moneyline (ML): 49ers -250 (bet $250 to win $100) | Falcons +205 (bet $100 to win $205)
Against the spread (ATS): 49ers -5.5 (-115) | Falcons +5.5 (-105)
Over/Under (O/U): 42.5 (O: -110 | U: -110)

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2022 betting stats

ML: 49ers 3-2 | Falcons 2-3
ATS: 49ers 3-2 | Falcons 5-0
O/U: 49ers 1-4 | Falcons 3-2

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49ers vs. Falcons head-to-head

Because they were division rivals in the NFC West before realignment in 2002, the 49ers and Falcons used to play each other twice a season. Including 2 playoff matchups, they have played 81 times dating back to 1966. The 49ers lead the all-time series 48-32-1.

They played last season with the Niners picking up a 31-13 home victory.

Including a playoff game after the 2012 season, the 49ers have won 4 of the last 5 meetings between the teams.

Garoppolo is 1-1 in 2 career starts against the Falcons, while Falcons QB Marcus Mariota is 1-0 in his 1 career start against the 49ers.

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NFL Week 6 betting odds: Moneylines, spreads and Over/Unders for all games

Looking at the NFL odds and lines for the Week 6 slate, with moneylines, spreads and Over/Unders for all games.

Week 5 saw the Houston Texans (1-3-1) pick up their first win of the 2022 season 13-6 over the Jacksonville Jaguars (2-3) as they dropped the mantle as the only winless team. The Philadelphia Eagles (5-0) kept their perfect record with a road win over the Arizona Cardinals (2-3) to keep rolling as the league’s lone undefeated squad. The Kansas City Chiefs (3-1) still have to host the Las Vegas Raiders (1-3) on Monday Night Football to wrap the week.

Week 6 gets underway with the Washington Commanders (1-4) visiting the Chicago Bears (2-3) on Thursday Night Football and is highlighted by the Buffalo Bills (4-1) at the Chiefs Sunday afternoon. The Eagles will look to maintain their unblemished record when they host the Dallas Cowboys (4-1) on Sunday Night Football.

Bye weeks are finally underway with the Detroit Lions, Tennessee Titans, Las Vegas Raiders and Houston Texans taking the week off.

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday, 5:40 a.m. ET

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Las Vegas Raiders at Kansas City Chiefs odds, picks and predictions

Analyzing Monday’s Las Vegas Raiders at Kansas City Chiefs odds and lines, with expert NFL picks, predictions and best bets.

The Las Vegas Raiders (1-3) head to GEHA Field at Arrowhead Stadium Monday night to face the Kansas City Chiefs (3-1). Kickoff is set for 8:15 p.m. ET (ESPN). Below, we analyze Tipico Sportsbook‘s lines around the Raiders vs. Chiefs odds, and make our expert NFL picks and predictions.

These AFC West rivals have faced off every year since 1960. The Chiefs lead the all-time series 70-54-2 and are 7-1 against the Raiders since the Patrick Mahomes era started in 2018. The Raiders’ only win against the Mahomes-led Chiefs came in 2020. The Chiefs defeated the Raiders twice last season by a combined score of 89-23.

The Raiders earned their 1st victory of 2022 in Week 4 over another AFC West rival, the Denver Broncos. It was also the 1st time the Raiders covered the spread this season. The Chiefs defeated the Tampa Bay Buccaneers 41-31 on Sunday Night Football last week, covering the spread for the 2nd time this season.

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Raiders vs. Chiefs odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 4:28 p.m. ET.

Moneyline (ML): Raiders +270 (bet $100 to win $270) | Chiefs -340 (bet $340 to win $100)
Against the spread (ATS): Raiders +7.5 (-115) | Chiefs -7.5 (+105)
Over/Under (O/U): 51.5 (O: -108 | U: -112)

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Raiders vs. Chiefs key injuries

Raiders

LB Jayon Brown (hamstring) out
TE Foster Moreau (knee) questionable
CB Sam Webb (hamstring) questionable

Chiefs

K Harrison Butker (ankle) out
DE Mike Danna (calf) questionable
RG Trey Smith (pec) questionable
WR JuJu Smith-Schuster (hamstring) questionable

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Raiders vs. Chiefs picks and predictions

Prediction

Chiefs 38, Raiders 24

Moneyline

The Chiefs have the Raiders’ number, and it doesn’t seem like that will change anytime soon. K.C. is rolling after easily taking down the Bucs in Tampa, while the Raiders’ lone win came against a Denver squad averaging just 15 points per game, the 2nd-lowest in the NFL.

The Chiefs are averaging the 2nd-highest points per game in the league (32.3) and should have no problem keeping that up against a middling-at-best Raiders defense. With that in mind, the Chiefs should win, but I would AVOID the moneyline since the payout to take K.C. is not worth the money spent.

Against the spread

The CHIEFS -7.5 (+105) is your best bet in this game. The juice allows a plus payout, and the Chiefs have blown out Vegas the last 2 times they’ve played. Mahomes has also enjoyed lots of success against the Raiders, throwing 22 TDs and 3 INTs and averaging 318.3 passing yards per game in his career against the silver and black. K.C. will run up the score, which makes the single-digit line an easy one.

Over/Under

Even in the Chiefs’ blowouts this season they’ve allowed a decent amount of points (31 against the Bucs and 21 against the Arizona Cardinals). That’s not necessarily because the K.C. defense is bad, but more because the defense tends to slide into prevent when the offense is scoring big.

With both the Raiders and Chiefs allowing nearly 25 points per game each and both offenses in the top 10 in scoring, this seems like an easy matchup to take the OVER 51.5 (-108). Plus, it’s a divisional game in prime time, so both squads will be putting forth their best effort.

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Cincinnati Bengals at Baltimore Ravens odds, picks and predictions

Analyzing Sunday’s Cincinnati Bengals at Baltimore Ravens odds and lines, with expert NFL picks, predictions and best bets.

The Cincinnati Bengals (2-2) head to M&T Bank Stadium on Sunday night to take on the Baltimore Ravens (2-2) in an AFC North battle. Kickoff is scheduled for 8:20 p.m. ET (NBC). Below, we analyze Tipico Sportsbook‘s lines around the Bengals vs. Ravens odds, and make our expert NFL picks and predictions.

The Bengals are coming off a long rest, beating the Miami Dolphins 27-15 two Thursday nights ago in a win that was largely overshadowed by a head injury to Dolphins QB Tua Tagovailoa. Bengals QB Joe Burrow seems to continually be finding his stride week after week, completing 20 of 31 passes for 287 yards and 2 TDs with WR Tee Higgins (7 catches, 124 yards, 1 TD) being his top receiver. Last season’s Offensive Rookie of the Year WR Ja’Marr Chase tacked on 4 receptions for 81 yards.

The Cincinnati run game is still a weak point though. RB Joe Mixon rushed 24 times for only 61 yards, but he did score his first TD of the season. On defense, S Vonn Bell anchored the Bengals with 2 interceptions, including a game-sealing pick late in the 4th quarter. The Bengals will need to continue to protect Burrow and look for a spark on the ground in order to claim a victory on the road this week.

The Ravens fell to the Buffalo Bills 23-20 in Week 4. After leading 20-10 at halftime, Baltimore did not score in the second half. QB Lamar Jackson had 1 TD pass and 2 interceptions behind only 144 yards passing. On the ground, he carried the ball 11 times for 73 yards, while RB J.K. Dobbins carried the ball 13 times for 41 yards and a score.

Dobbins (4 receptions, 22 yards) caught the only Ravens TD pass of the day, too. Penalties ended up hurting the Ravens, who were flagged 9 times for 70 yards. Baltimore’s defense forced 2 turnovers, an interception and fumble, but it could not stop Buffalo late.

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Bengals at Ravens odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 11 a.m. ET.

Moneyline (ML): Bengals +140 (bet $100 to win $140) | Ravens -165 (bet $165 to win $100)
Against the spread (ATS): Bengals +3.5 (-125) | Ravens -3.5 (+100)
Over/Under (O/U): 47.5 (O: -105 | U: -115)

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Bengals at Ravens key injuries

Bengals

WR Tee Higgins (ankle) questionable
TE Hayden Hurst (groin) questionable

Ravens

WR Rashod Bateman (foot) out
LB Justin Houston (groin) out
CB Marcus Peters (quadriceps) questionable
OL Ronnie Stanley (ankle) questionable

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Bengals at Ravens picks and predictions

Prediction

Bengals 28, Ravens 24

Moneyline

LEAN BENGALS (+140).

The Bengals have been finding their stride recently as the offensive line gets more reps together after acquiring 4 new starting linemen this offseason.

They have been able to protect Burrow more each week and that will be a crucial part of the game. The Bengals will also look to Mixon to open up the ground attack and take pressure off the receivers.

Against the spread

TAKE BENGALS +3.5 (-125).

Cincinnati is 4-1 ATS in its last 5 games in Baltimore and the road team is 5-2 ATS in the last 7 matchups between these two.

Cincinnati crushed Baltimore twice last season, winning both games by more than 2 scores – beating the Ravens 41-21 at Cincy and 41-17 at Baltimore.

With the amount of offensive firepower Cincinnati has and with its defense becoming more dominant each week, expect the Bengals to keep this game within a field goal.

Over/Under

BET OVER 47.5 (-105).

These are 2 high-powered offenses that are both capable of putting up a lot of points.

Jackson and the Ravens have had success recently with their duality on the ground, while Burrow and the Bengals have found success through their explosive receivers.

Baltimore ranks 3rd in the NFL in rushing yards per attempt (5.4 yards) and should be able to run on Cincinnati, which is down its best run-stopper, DT D.J. Reader (knee). Cincinnati has scored 27 points in back-to-back weeks.

Expect big plays and a lot of points in this primetime matchup.

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SportsbookWire’s NFL Week 5 picks: ML, ATS and O/U predictions for all games

SportsbookWire writers make their NFL Week 5 picks and predictions for money lines, spreads and totals.

There seems to be a trend here.

The largest underdog each week covers!

Before getting to SportsbookWire staff’s Week 5 NFL picks, here’s a recap of those big dogs. All closing lines courtesy of Covers.com.

Week 4 – New England Patriots (+9.5) covered in 27-24 OT loss at Green Bay Packers

Week 3 – Jacksonville Jaguars (+7.5) won 38-10 at Los Angeles Chargers

Week 2 – Atlanta Falcons (+12.5) covered in 31-27 loss at Los Angeles Rams

Week 1 – Pittsburgh Steelers (+7.5) upset host Cincinnati Bengals 23-20 in OT

Week 1b – Houston Texans (+7.5) tied visiting Indianapolis Colts 20-20

Up next – Steelers (+13.5) at Buffalo Bills, Sunday 1 p.m. ET

We’ll soon find out if rookie QB Kenny Pickett, who is getting his 1st start, and Pittsburgh keep the trend going?

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In Week 4, underdogs went 8-8 against the spread (ATS) but were 6-10 straight up (SU). For the season, dogs hold a 36-27-1 ATS advantage but are 27-36-1 SU.

Unders lead Overs for the season 38-25-1 after splitting 8-8 last week.

Week 5 kicked off with the Colts needing overtime to win at the Denver Broncos 12-9 Thursday night. Indy improved to 2-2-1, while Denver fell to 2-3.

Sunday’s action begins with another London game as the New York Giants (3-1) face the Packers (3-1), who are the designated home team, at 9:30 a.m. ET

The two 4:25 p.m. ET games involve the undefeated Philadelphia Eagles (4-0) visiting the Arizona Cardinals (2-2), and the Dallas Cowboys (3-1) taking on the defending champion Rams (2-2).

The Sunday night game features an AFC North showdown of the Bengals (2-2) at the Baltimore Ravens (2-2) at 8:20 p.m. ET.

The week concludes with the Kansas City Chiefs (3-1) hosting the Las Vegas Raiders (1-3) at 8:15 p.m. ET Monday night.

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Check out our staff predictions before locking in your Week 5 NFL picks.

NFL Week 5 staff picks

NFL Week 5 odds, picks and predictions

Parlay: Let’s make some money
Best picks: Underdogs | Player props | Survivor

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Detroit Lions at New England Patriots odds, picks and predictions

Analyzing Sunday’s Detroit Lions at New England Patriots odds and lines, with expert NFL picks, predictions and best bets.

The Detroit Lions (1-3) visit the New England Patriots (1-3) Sunday in Week 5. Kickoff from Gillette Stadium is scheduled for 1 p.m. ET (FOX). Below, we analyze Tipico Sportsbook’s lines around the Lions vs. Patriots, and make our expert NFL picks and predictions.

Both teams are on 2-game slides after losing their openers and winning in Week 2.

The big news is the Patriots will start 3rd-string rookie QB Bailey Zappe. Starter Mac Jones is out with an ankle injury – suffered during a 37-26 home loss in Week 3 to the Baltimore Ravens – and backup Brian Hoyer is on IR with a concussion – sustained in last week’s 27-24 OT loss at the Green Bay Packers.

Zappe played most of the Packers game, entering on the Patriots’ 2nd series when Hoyer was hurt. In his unexpected NFL debut, the 4th-round 2022 draft pick out of Western Kentucky completed 10 of 15 passes for 99 yards with a TD and no picks as New England, the NFL’s biggest underdog of the week, covered a 10-point spread in the loss.

Detroit lost 48-45 at home to the Seattle Seahawks in Week 4, failing to cover the spread for the 1st time this season. The Lions, who were 3-point favorites, couldn’t stop the Seahawks offense, which never had to punt and finished with 555 yards, including 235 on the ground. Detroit did have more 1st downs (19-14) and more passing yards (375-320), but it could never get over the hump after falling into a 7-0 hole on Seattle’s opening drive.

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Lions at Patriots odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:31 a.m. ET.

Moneyline (ML): Lions +140 (bet $100 to win $140) | Patriots -165 (bet $165 to win $100)
Against the spread (ATS): Lions +3.5 (-120) | Patriots -3.5 (-101)
Over/Under (O/U): 45.5 (O: -112 | U: -108)

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Lions at Patriots key injuries

Lions

C Evan Brown (ankle) questionable
WR DJ Chark (ankle) out
DL Charles Harris (groin) out
OL Jonah Jackson (finger) questionable
WR Josh Reynolds (ankle) questionable)
WR Amon-Ra St. Brown (ankle) questionable
RB D’Andre Swift (shoulder, ankle) out

Patriots

S/KR Kyle Dugger (knee) questionable
DL Lawrence Guy (shoulder) out
QB Brian Hoyer (concussion) out
QB Mac Jones (ankle) doubtful
LB Raekwon McMillan (thumb) questionable
WR Jakobi Meyers (knee) questionable
CB Jalen Mills (hamstring) questionable
S Adrian Phillips (ribs) questionable
TE Jonnu Smith (ankle) doubtful
OL Isaiah Wynn (hip) questionable

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Lions at Patriots picks and predictions

Prediction

Lions 31, Patriots 17

Moneyline

BET 0.25 UNITS ON DETROIT (+145).

The Lions haven’t won a road game since Week 13 of the 2020 season (at the Chicago Bears 34-30), but with the Patriots’ QB situation, Detroit has a distinct advantage Sunday.

While Zappe surprised many by keeping New England in last week’s game at Green Bay after Hoyer’s exit, the truth of the matter is the Packers are not that good.

Expect coach Dan Campbell to have the Lions more than ready for this game as they snap their road losing streak.

Against the spread

DETROIT +3.5 (-120) is the STRONGEST PLAY – usually 1½ times your usual wager, but let’s make it 1.25 TIMES since we’re playing a quarter unit on the ML.

ATS records: Lions 3-1 | Patriots 1-2-1

Be warned: Detroit’s defense is not good. It ranks last in yards (444.8) and points (35.3) allowed per game.

But I don’t see New England’s offense being productive with a backup to the backup QB.

Offensively, Detroit leads the NFL in yards (436.8) and points (35.0) per game. The Patriots are 19th (341.3 YPG) and 23rd (18.5 PPG), respectively.

Defensively, the Patriots allow 346.8 yards (19th) and 24.5 points (24th) per game.

Over/Under

BACK OVER 45.5 (-112) for 0.75 UNITS.

O/U records: Lions 4-0 | Patriots 2-2

If the Patriots had a more experienced QB, this would have been the “strongest play.” The line likely would be higher with a better New England QB, but the offensive and defensive stats mentioned above speak for themselves.

Plus, the Over is 7-0 in the last 7 Patriots’ home games, while it is 6-0 in the Lions’ last 6 games overall.

The reason for doubt in not playing a full unit is the question marks revolving around New England’s offense with Zappe under center.

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Pittsburgh Steelers at Buffalo Bills odds, picks and predictions

Analyzing Sunday’s Pittsburgh Steelers at Buffalo Bills odds and lines, with expert NFL picks, predictions and best bets.

The Pittsburgh Steelers (1-3) and Buffalo Bills (3-1) meet Sunday at Highmark Stadium. Kickoff is set for 1 p.m. ET (CBS). Below, we analyze Tipico Sportsbook‘s lines around the Steelers vs. Bills odds, and make our expert NFL picks and predictions.

Steelers rookie QB Kenny Pickett played in his 1st NFL game in a 24-20 loss to the New York Jets last Sunday. Pickett threw for 120 yards and 3 INTs on 10-of-13 passing as Pittsburgh failed to cover as a 3-point favorite.

Pittsburgh is 1-3-1 against the spread (ATS) in its last 5 games.

Bills K Tyler Bass made a game-winning 21-yard FG in a 23-20 win at the Baltimore Ravens last Sunday. QB Josh Allen finished with 213 yards, 1 passing TD and 1 INT and ran for a score.

Buffalo is 9-1-2 ATS vs. teams with a losing record.

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Steelers at Bills odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:01 a.m. ET.

Moneyline (ML): Steelers +650 (bet $100 to win $650) | Bills -1000 (bet $1,000 to win $100)
Against the spread (ATS): Steelers +13.5 (-103) | Bills -13.5 (-117)
Over/Under (O/U): 45.5 (O: -108 | U: -112)

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Steelers at Bills injuries

Steelers

S Terrell Edmunds (concussion) out
CB Cameron Sutton (hamstring) questionable
CB Ahkello Witherspoon (hamstring) out

Bills

CB Christian Benford (hand) out
WR Jamison Crowder (ankle) out
OL Tommy Doyle (knee) out
LB Tremaine Edmunds (hamstring) questionable
S Micah Hyde (neck) out
TE Dawson Knox (foot) out
WR Jake Kumerow (ankle) out
WR Isaiah McKenzie (concussion) questionable
DL Ed Oliver (ankle) questionable
DL Jordan Phillips (hamstring) questionable
S Jordan Poyer (undisclosed) out
CB Tre’Davious White (knee) out

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Steelers at Bills picks and predictions

Prediction

Bills 31, Steelers 10

Want action on this NFL game or any other matchups? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

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