The Arizona Cardinals play their final home game of the season in Week 16 on Christmas night facing the Tampa Bay Buccaneers. It will be only the third time Tom Brady starts against them.
The two teams kick off Sunday night at 8:20 p.m. ET at State Farm Stadium and will air on NBC. Below, we look at the betting odds and lines for the Bucs at Cardinals Week 16 matchup, based on BetMGM odds for Week 16.
The 4-10 Cardinals are coming off a 24-15 loss to the Denver Broncos, their fourth straight loss. They also might be without quarterback Colt McCoy, who suffered a concussion in the loss.
The Bucs lead the NFC South with only a 6-8 record and are coming off a 34-13 loss to the Cincinnati Bengals. They have lost two in a row.
Buccaneers at Cardinals Week 16 odds and lines
Moneyline:
- Buccaneers -250 (bet $250 to win $100)
- Cardinals +200 (bet $100 to win $200)
The Bucs are 6-8 straight up and 2-4 on the road. At -250 odds, they are given 71.43% implied odds of winning. It would take a $250 wager on the Bucs to win $100 if they win the game.
ATS (Against the spread)
- Buccaneers -6 (-110)
- Cardinals +6 (-110)
The Buccaneers are 3-10-1 ATS this season. They opened the week as four-point favorites. A $110 ATS bet in Tampa Bay wins $100 if the Bucs beat the Cardinals by more than six points.
The Cardinals are 6-8 ATS on the season. A $110 ATS wager wins $100 if the Cardinals beat the Bucs, the game ends in a tie or they lose by five or fewer points.
Total (Over/Under)
- Over 41.5 (-110)
- Under 41.5 (-110)
A $110 bet on the Over wins $100 if the two teams combine for 42 points or more.
A $110 bet on the Under wins $100 if they combine for 41 or fewer points.
The Bucs are 4-10 O/U this season and the Cardinals are 8-6 O/U.
Buccaneers vs. Cardinals history
Dating back to 1977, the Cardinals and Bucs have faced each other only 21 times. The Cardinals hold a slight 11-10 advantage in the all-time series.
The Bucs won the last matchup 30-27 in 2019. Cardinals QB Kyler Murray threw 3 TD passes but the Bucs got the go-ahead touchdown with under two minutes left in the game.
The Cardinals had won the three previous meetings.
Cardinals QB Colt McCoy has never started against the Buccaneers in his career. Bucs QB Tom Brady has only started against the Cardinals twice in his career. He is 1-1 against them and his only win against them was in 2004.