Betting the NFL Line: Week 4

A league-wide view into the best wagers to make for NFL Week 4 action.

Week 4 looks to be one of the more competitive in the NFL that we may see the rest of year, because injuries will take a greater toll on more teams as the season progresses.

On this week’s schedule, 10 of the 16 games have point spreads of 3.5 or less. You see that in Week 1 but almost never after that … except this week.

Odds provided by BetMGM Sportsbook


Dallas Cowboys (-275) at New York Giants (+220)

The Cowboys are strong road favorites (6 points at -110 for both teams). The fans in Dallas are losing their minds over the slow start. The Giants don’t have the horses to run with them. If Dallas gets the lead, it will keep the pressure on all day. Take the Cowboys and lay 6 points (-110).


New Orleans Saints (+115) at Atlanta Falcons (-135)

The Falcons are slight favorites (2.5 points at -110 for both the Saints and Falcons). This rivalry is always played close and being at home is often enough of an advantage for both. This time, it’s Atlanta’s turn. Take the Falcons and lay 2.5 points (-110).


Cincinnati Bengals (-215) at Carolina Panthers (+170)

The Bengals are small road favorites (4 points at -110 for both). The Bengals have been hard-luck losers three times. They are too good to fall on their face again. Cincinnati may win by 14 or more if it gets in a groove. Take the Bengals and lay 4 points (-110).


Los Angeles Rams (+125) at Chicago Bears (-150)

The Over/Under is 41 points (-110 for both Over and Under). The Rams are severely undermanned missing their receiving stars, but Matthew Stafford can still get the job done. The Bears are due to get their talented offense to start clicking. Take OVER 41 points (-110).


Minnesota Vikings (+115) at Green Bay Packers (-135)

The Vikings have beaten the 49ers and Texans. They have done it with defensive dominance, including 16.5 sacks. The Packers have teased that Jordan Love may be back, but the better long-term move is to hold off bringing him back too soon … especially against this defense. Take the Vikings on the moneyline (+115).


Jacksonville Jaguars (+240) at Houston Texans (-300)

The Over/Under is middle of the road (45 points for both Over and Under). Divisional games are typically played tight to the vest. Considering the Texans haven’t scored 20 points in the last two games and the Jags haven’t scored more than 17 points all year, this number seems little high under current circumstances. Take Under 45 points (-110).


Pittsburgh Steelers (-125) at Indianapolis Colts (+105)

The Over/Under is low (40 points at -110 for both teams). This one features two of the most dynamic dual-threat quarterbacks in Justin Fields and Anthony Richardson. Between the two of them, there should be enough big plays to have both teams get in scoring position enough times. Take Over 40 points (-110).


Denver Broncos (+300) at New York Jets (-375)

The Jets are big favorites (7.5 points at -110 for both teams). Aaron Rodgers has looked like the Rodgers of old the last couple weeks and is coming into this one with extra rest. It will take New York mistakes not to cover. Take the Jets and lay 7.5 points (-110).


Philadelphia Eagles (-130) at Tampa Bay Buccaneers (+105)

The Eagles are small road favorites (2 points at -110 for both teams). Philadelphia is depleted at wide receiver but has proved it can win with a Saquon Barkley-led rushing offense and an oppressive defense. Take the Eagles and lay 2 points (-110).


Washington Commanders (+145) at Arizona Cardinals (-175)

This is the highest Over/Under of the week (50.5 points at -110 for both). Jayden Daniels showed in prime time on the road that he can be dominant, and Kyler Murray is a dangerous playmaker. This has the makings of a back-and-forth battle that will light up the scoreboard. Take OVER 50.5 points (-110).


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New England Patriots (+450) at San Francisco 49ers (-650)

The Over/Under is low (40.5 points at -110 for both). The Patriots can’t hang with the 49ers defense, and San Francisco’s depleted receiver corps could have them running a lot – especially if holding a double-digit lead in the second half. Take Under 40.5 points (-110).


Kansas City Chiefs (-400) at Los Angeles Chargers (+310)

The Chiefs are big road favorites (7.5 points at -110 for both teams). Without Justin Herbert, the Chargers offense is weakened, which you should never have against the two-time defending champs smelling blood. Take the Chiefs and lay 7.5 points (-110).


Cleveland Browns (+110) at Las Vegas Raiders (-130)

The Browns entered this season with Super Bowl dreams but have sputtered out of the gate. The Raiders are similarly erratic. Cleveland has one of the NFL’s best defenses and will show it against a Raiders team contemplating a change at QB. Take the Browns on the moneyline (+110).


Buffalo Bills (+110) at Baltimore Ravens (-130)

The Over/Under is pretty high (46.5 points at -110 for both Over and Under). Expect fireworks any time you get Lamar Jackson and Josh Allen together. Because of their explosiveness, if one team gets ahead by 10 points, it won’t go into a shell. Take OVER 46.5 points (-110).


Tennessee Titans (+100) at Miami Dolphins (-120)

The Dolphins are minimal favorites (1 point at -110 for both teams). It’s hard to take Miami while likely on its third QB, but Mike McDaniel will scheme ways to use the ground game to make big plays. And there’s always a chance Will Levis will give them six points with a bad decision. Take the Dolphins and lay 1 point (-110).


Seattle Seahawks (+155) at Detroit Lions (-190)

The Lions are a small home favorite (3.5 points at -110 for both teams). The Seahawks are off to a great start, but Detroit in prime time will be deafening for Seattle’s offense to operate. The Lions will seize on the momentum and, if they get on a roll, that momentum will snowball. Take the Lions and lay 3.5 points (-110).