New England Patriots at San Francisco 49ers odds, picks and predictions

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The New England Patriots (1-2) visit the San Francisco 49ers (1-2) Sunday. Kickoff from Levi’s Stadium is scheduled for 4:05 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Patriots vs. 49ers odds, and make our expert NFL picks and predictions.

After winning their first game of the season, the Patriots have dropped 2 straight. They lost 24-3 as 6.5-point underdogs at the New York Jets Sept. 19. QB Jacoby Brissett went 12 of 18 for 98 yards before getting pulled for QB Drake Maye, who went 4 of 8 for 22 yards. New England had just 78 yards on the ground in the loss.

The 49ers have also dropped back-to-back games after winning their opener. They lost 27-24 as 6.5-point favorites at the LA Rams in Week 3. QB Brock Purdy went 22 of 30 for 292 yards with 3 touchdowns, all to WR Jauan Jennings who had 11 receptions for 175 yards.

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Patriots at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 1:35 p.m. ET.

Moneyline (ML): Patriots +425 (bet $100 to win $425) | 49ers -600 (bet $600 to win $100)
Against the spread (ATS): Patriots +10.5 (-110) | 49ers -10.5 (-110)
Over/Under (O/U): 40.5 (O: -110 | U: -110)

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Patriots at 49ers key injuries

Patriots

CB Alex Austin (ankle) out
LB Anfernee Jennings (shoulder) questionable
CB Jonathan Jones (shoulder) questionable
G Mike Jordan (ankle) out
T Vederian Lowe (knee) out
G Sidy Sow (ankle) questionable
T Caedan Wallace (knee) questionable

49ers

DT Jordan Elliott (foot) questionable
LB Dre Greenlaw (Achilles) out
DT Javon Hargrave (triceps) out
S Talanoa Hufanga (ankle) questionable
RB Christian McCaffrey (Achilles) out
WR Deebo Samuel Sr. (calf) questionable
T Trent Williams (illness, toe) questionable

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Patriots at 49ers picks and predictions

Prediction

49ers 31, Patriots 13

Moneyline

PASS.

There is no value on the 49ers (-600) to win Sunday.

Against the spread

BET 49ERS -10.5 (-110).

While underdogs have fared well both outright and ATS this season, that will not be the case in this matchup. The Niners found a lot of success last week against the Rams, leading by as many as 14 points before a 4th-quarter collapse. Against the Patriots, expect San Francisco to get back on track with a statement win.

Over/Under

BET OVER 40.5 (-110).

The 49ers will have to carry a majority of the load in order for the Over to hit. They have scored 24 or more points in 2 of 3 games this season and allowed 19 or more in all 3. With many players returning from injury this week, Purdy will have more targets and opportunities to put the ball in the end zone against a weak New England defense.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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