The Houston Texans released their 2021 NFL schedule Wednesday.
| Week | Date | Opponent | Time |
| 1 | Sept. 12 | vs. Jacksonville Jaguars | 12:00 p.m. CT |
| 2 | Sept. 19 | at Cleveland Browns | 12:00 p.m. CT |
| 3 | Sept. 23 | vs. Carolina Panthers | 7:20 p.m. CT |
| 4 | Oct. 3 | at Buffalo Bills | 12:00 p.m. CT |
| 5 | Oct. 10 | vs. New England Patriots | 12:00 p.m. CT |
| 6 | Oct. 17 | at Indianapolis Colts | 12:00 p.m. CT |
| 7 | Oct. 24 | Arizona Cardinals | 3:25 p.m. CT |
| 8 | Oct. 31 | vs. Los Angeles Rams | 12:00 p.m. CT |
| 9 | Nov. 7 | at Miami Dolphins | 12:00 p.m. CT |
| 10 | BYE | WEEK | |
| 11 | Nov. 21 | at Tennessee Titans | 12:00 p.m. CT |
| 12 | Nov. 28 | vs. New York Jets | 12:00 p.m. CT |
| 13 | Dec. 5 | vs. Indianapolis Colts | 12:00 p.m. CT |
| 14 | Dec. 12 | vs. Seattle Seahawks | 12:00 p.m. CT |
| 15 | Dec. 19 | at Jacksonville Jaguars | 12:00 p.m. CT |
| 16 | Dec. 26 | vs. Los Angeles Chargers | 12:00 p.m. CT |
| 17 | Jan. 2 | at San Francisco 49ers | 3:05 p.m. CT |
| 18 | Jan. 9 | vs. Tennessee Titans | 12:00 p.m. CT |
All games will be broadcast on the radio in Houston on Sports Radio 610 [KILT-AM] and across the Texans Radio Network.
Here are some takeaways from the schedule.