Philadelphia Eagles at Arizona Cardinals odds, picks and prediction

Previewing the Philadelphia Eagles at Arizona Cardinals Week 15 betting odds and lines, with NFL betting picks, tips and predictions.

The Arizona Cardinals (7-6) are back home in Week 15 to take on the Philadelphia Eagles (4-8-1). Kickoff is at 4:05 p.m. ET at State Farm Stadium in Glendale, AZ.

Below, we preview the Eagles-Cardinals betting odds and lines and make our NFL picks and predictions.

Eagles at Cardinals: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 1:45 a.m. ET.

  • Money line: Eagles +225 (bet $100 to win $225) | Cardinals -275 (bet $275 to win $100)
  • Against the spread/ATS: Eagles +6.5 (-110) | Cardinals -6.5 (-110)
  • Over/Under: 49.5 (O: -110 | U: -110)

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Eagles at Cardinals: Game notes

  • Eagles QB Jalen Hurts will be making his second NFL start. In his first start, a win over the New Orleans Saints, he passed for 167 yards and a touchdown and rushed for 106 yards on 18 carries.
  • Philadephia is only 26th in the league in offense, averaging 326.3 yards per game. They are 27th in scoring, averaging 21.3 points per game.
  • Cardinals OLB Haason Reddick had five sacks and three forced fumbles in Week 14 and was named NFC Defensive Player of the Week. The Cardinals had eight sacks as a team.
  • Cardinals QB Kyler Murray has a combined 33 touchdowns. He has passed for 23 and rushed for 10.
  • The Cardinals are fourth in total offense and fourth in rushing offense.

Eagles at Cardinals: Key injuries

Eagles

  • RT Jack Driscoll (knee) out
  • CB Avante Maddox (knee) out
  • CB Darius Slay (concussion) questionable
  • DL Malik Jackson (concussion) questionable

Cardinals

  • DL Jordan Phillips (hamstring) out
  • Jalen Thompson (ankle) doubtful
  • OL Justin Pugh (calf) questionable
  • RB Chase Edmonds (ankle) questionable
  • CB Dre Kirkpatrick (hamstring) questionable
  • LT Kelvin Beachum (back) questionable

Eagles at Cardinals: Odds, betting lines, predictions and picks

Prediction

Cardinals 31, Eagles 17

Money line (?)

The Cardinals got back on track after three straight losses in a 26-7 win over the New York Giants in Week 14. The Eagles beat the Saints after four straight losses.

The Cardinals are playing for the playoffs and the Eagles are trying to get back into the picture in the NFC East. But Philly’s secondary and offensive line are too banged up to stop the Cardinals’ pass rush and offense.

TAKE THE CARDINALS (-275).

Against the spread (?)

The Cardinals faced a similarly built team in the Washington Football Team earlier this season. They easily won 30-15. Philadelphia is only 1-5 ATS on the road and 1-2 ATS after a win.

TAKE THE CARDINALS -6.5 (-110).

Over/Under (?)

The Cardinals have the second-lowest Over percentage in the league at 30.8%. Philly isn’t much better at 38.5%. The Cardinals had five straight games with at least 30 points earlier in the season and appeared to get the offense back on track last week. Philadelphia’s 24 points in Week 14 were the most they scored in seven games.

TAKE UNDER 49.5 POINTS (-110).

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