5 Best College Football Predictions Against The Spread: Week 1 Friday

What games appear to be the best bets and the best picks against the spread going into the Friday of Week 1 of the college football season?

1. Duke vs. Charlotte

LINEDuke -6.5
ATS PICK: Duke

Yeah, there’s some Power Five snobbery at play here, and yeah, the 53-19 Blue Devil win last season has something to do with it.

Maybe the line is low because it’s at a neutral site – sort of.

Maybe it’s because the Duke defense doesn’t seem like it’s going to be anything special.

Maybe Charlotte appears to be more like the 2019 version than the 2020 team that went 2-4 during the global pandemic season.

Nah … the world is giving us a Power Five team by less than a touchdown.

Charlotte has yet to beat a Power Five team since it arrived in the FCS world in 2015. There have been a few decent wins – like against Marshall in 2019 and UAB in 2017 – but nothing all that great.

It’s a brand new year and anything and everything can happen, but you’re asking to buck history here with what would be the greatest game in Charlotte football history if it could pull this off.

It would be historic if it could just keep this to under seven points.

Duke can’t take anyone lightly, and the Charlotte offense will be fun, but …

Take the Power Five team giving away less than a touchdown.

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