The New Orleans Saints are set to host the San Francisco 49ers on Sunday at 12:00 p.m. C.T. in the Mercedes-Benz Superdome. After the Seattle Seahawks’ victory on Monday Night Football, the Saints now hold the number one seed in the projected NFC playoff picture heading into their clash with the 49ers. A victory here can go a long way towards sealing it.

Both New Orleans and San Francisco have a lot to play for this Sunday. The Saints could solidify their hold on the number one seed in the conference, while the 49ers will look to reclaim their lead in the NFC West and get out of a wild-card spot.

This game will come down to which side can win several key matchups. We’ve broken down a few that could have huge implications on the outcome:

Saints RT Ryan Ramczyk vs. 49ers DE Nick Bosa

Ryan Ramczyk has been an absolutely lockdown tackle for New Orleans this year. His continued success this season has allowed the Saints offense to run efficiently. This year alone, Ramczyk has made the likes of J.J. Watt, Jadeveon Clowney, Dante Fowler, and Shaquil Barrett look pedestrian.

Nick Bosa could pose to be Ramczyk’s toughest foe yet. Bosa is the leading candidate for Defensive Rookie of the Year with his eight sacks, 24 tackles, and one interception. However, his contributions go well beyond just the statline. His ability to constantly put pressure on the quarterback disrupts the offense immensely. Ramczyk will have his work cut out for him on Sunday.